The Effectiveness of Taurolidine Antimicrobial Locks in Preventing Catheter-Related Bloodstream Infections (CRBSIs) in Children Receiving Parenteral Nutrition: A Case Series
Galina Ling,
Shalom Ben-Shimol,
Siham Elamour,
Raouf Nassar,
Eyal Kristal,
Rotem Shalev,
Gadi Howard,
Baruch Yerushalmi,
Slava Kogan,
Moshe Shmueli
Affiliations
Galina Ling
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Shalom Ben-Shimol
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Siham Elamour
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Raouf Nassar
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Eyal Kristal
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Rotem Shalev
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Gadi Howard
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Baruch Yerushalmi
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Slava Kogan
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Moshe Shmueli
The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
Introduction: We assessed the efficacy of taurolidine lock (TL) in preventing catheter-related bloodstream infections (CRBSIs) and related hospitalizations in children with parenteral nutrition (PN) in the home setting. Methods: This study is a retrospective case series study. All children with intestinal failure in a single center in southern Israel who were administered PN and treated with TL between 2017 and 2024 were included. The rates of CRBSI episodes, related hospitalizations and pathogen distribution in the pre-TL and post-TL periods were compared. Results: Overall, 14 patients were included. The median pre-TL and post-TL periods were 990 and 1260 days, respectively. The rate of CRBSI episodes due to bacterial infection per 1000 days declined by 45%, from 6.2 to 3.7, with p = 0.0008, while fungal CRBSI rates were low (p = 0.001. Conclusions: Taurolidine lock treatment for children with central-line PN resulted in a substantial decrease in CRBSI episodes and related hospitalizations.
