Early antiinflammatory therapy attenuates brain damage after sah in rats

Abstract

Early inflammatory processes may play an important role in the development of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Experimental studies suggest that anti-inflammatory and membrane-stabilizing drugs might have beneficial effects, although the underlying mechanisms are not fully understood. The aim of this study was to investigate the effect of early treatment with methylprednisolone and minocycline on cerebral perfusion and EBI after experimental SAH.

Keywords

• subarachnoid hemorrhage
• early brain injury
• methylprednisolone
• minocycline
• neuroprotection