Unwinding of a DNA replication fork by a hexameric viral helicase

Abid Javed; Balazs Major; Jonathan A. Stead; Cyril M. Sanders; Elena V. Orlova

doi:10.1038/s41467-021-25843-6

Nature Communications (Sep 2021)

Unwinding of a DNA replication fork by a hexameric viral helicase

Abid Javed,
Balazs Major,
Jonathan A. Stead,
Cyril M. Sanders,
Elena V. Orlova

Affiliations

Abid Javed: Department of Biological Sciences, Birkbeck College, Institute of Structural and Molecular Biology
Balazs Major: Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Medical School
Jonathan A. Stead: Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Medical School
Cyril M. Sanders: Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Medical School
Elena V. Orlova: Department of Biological Sciences, Birkbeck College, Institute of Structural and Molecular Biology

DOI: https://doi.org/10.1038/s41467-021-25843-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Replicative hexameric helicases are fundamental components of replisomes. Here the authors resolve a cryo-EM structure of the E1 helicase from papillomavirus bound to a DNA replication fork, providing insights into the mechanism of DNA unwinding by these hexameric enzymes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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