Nature Communications (Mar 2019)
Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3 neg regulatory CD4+ T cells in pancreatic carcinoma
- Rocky M. Barilla,
- Brian Diskin,
- Raul Caso Caso,
- Ki Buom Lee,
- Navyatha Mohan,
- Chandan Buttar,
- Salma Adam,
- Zennur Sekendiz,
- Junjie Wang,
- Ruben D. Salas,
- Marcelo F. Cassini,
- Jason Karlen,
- Belen Sundberg,
- Hashem Akbar,
- Dmitry Levchenko,
- Inderdeep Gakhal,
- Johana Gutierrez,
- Wei Wang,
- Mautin Hundeyin,
- Alejandro Torres-Hernandez,
- Joshua Leinwand,
- Emma Kurz,
- Juan A. Kochen Rossi,
- Ankita Mishra,
- Miguel Liria,
- Gustavo Sanchez,
- Jyoti Panta,
- P’ng Loke,
- Berk Aykut,
- George Miller
Affiliations
- Rocky M. Barilla
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Brian Diskin
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Raul Caso Caso
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Ki Buom Lee
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Navyatha Mohan
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Chandan Buttar
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Salma Adam
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Zennur Sekendiz
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Junjie Wang
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Ruben D. Salas
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Marcelo F. Cassini
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Jason Karlen
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Belen Sundberg
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Hashem Akbar
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Dmitry Levchenko
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Inderdeep Gakhal
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Johana Gutierrez
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Wei Wang
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Mautin Hundeyin
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Alejandro Torres-Hernandez
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Joshua Leinwand
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Emma Kurz
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Juan A. Kochen Rossi
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Ankita Mishra
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Miguel Liria
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Gustavo Sanchez
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- Jyoti Panta
- Department of Microbiology, New York University School of Medicine
- P’ng Loke
- Department of Microbiology, New York University School of Medicine
- Berk Aykut
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- George Miller
- S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-09416-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Pancreatic ductal adenocarcinoma is characterized by a highly immunosuppressive tumour microenvironment. Here, the authors show that specialized subsets of tumour-infiltrating dendritic cells induce distinct CD4+ T cell programs and specifically identify a CD103–CD11b+ subset which induces tumor-promoting FoxP3– Type-1 regulatory T cells.
