THE EFFICIENCY OF USING THE MEDICATION COMBING 150 MG OF ISONIAZID , 375 MG OF PYRAZINA MIDE , 150 MG OF RI FAMPICIN IN THE TREATMEN T OF RESPIRATOR Y TUBERCULOSIS IN CHILDREN

Abstract

The main problem for treatment of children with various manifestations of tuberculosis is the lack of pediatric dosages of anti-tuberculosis drugs. Considering the current problems when providing treatment it is important to use combined medications with fixed pediatric dosages, which would significantly help to simplify the administration of medications and to relieve the psychological, emotional and physical load when taking a significant number of drugs.Goal of the study: to define the efficiency of using fixed doses of the medication combing 150 mg of isoniazid, 375 mg of pyrazinamide, 150 mg of rifampicin. Clinical, X-ray and laboratory rates were assessed during treatment of 73 children suffering from respiratory tuberculosis, of them 34 children were treated by the medication combing 150 mg of isoniazid, 375 mg of pyrazinamide, 150 mg of rifampicin plus ethambutol, and the other children were treated by the standard chemotherapy. The opportunity of effective use of the medication combining 150 mg of isoniazid, 375 mg of pyrazinamide, 150 mg of rifampicin in children was confirmed by positive results by the completion of the intensive phase of treatment as well as the continuation phase and minimization of adverse reactions during treatment. The combination of active components of the medication and doses is convenient for use, allow conducting directly observed treatment and enhancing the efficiency of chemotherapy.

Keywords

• туберкулез органов дыхания
• дети
• комбинированный препарат с фиксированными дозами
• нежелательные реакции
• эффективность терапии