Repositioning of Dantrolene as a Multitarget Agent for Neurodegenerative Diseases
Isabella Bolognino,
Marco Catto,
Leonardo Pisani,
Saverio Cellamare,
Cosimo D. Altomare,
Nicola Giangregorio
Affiliations
Isabella Bolognino
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, via E. Orabona 4, 70125 Bari, Italy
Marco Catto
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, via E. Orabona 4, 70125 Bari, Italy
Leonardo Pisani
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, via E. Orabona 4, 70125 Bari, Italy
Saverio Cellamare
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, via E. Orabona 4, 70125 Bari, Italy
Cosimo D. Altomare
Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, via E. Orabona 4, 70125 Bari, Italy
Nicola Giangregorio
National Research Council, Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (CNR-IBIOM), via G. Amendola 122/O, 70126 Bari, Italy
Dantrolene is an orphan drug representing the sole therapeutic treatment for malignant hyperthermia, a life-threatening pathology affecting 0.2 in every 10,000 people in the EU. [...]
