Multidrug-Resistant Enterobacteriaceae Colonizing Gastrointestinal Tract in Infants with Congenital Heart Disease on Admission to Cardiac Surgery Hospital

Abstract

We studied 126 children, admitted to cardiac surgery hospital with colonization of the gastrointestinal tract (GIT) by multidrug-resistant Enterobacteriaceae. Criterion for inclusion in the study were children with complex congenital heart disease before the age of 1 year, with a previous hospitalization. Study was performed from April to December in 2013. In 51 (40.5%) patients colonization of the GIT by MDR-Enterobacteriaceae was detected. In 49 (38.9%) cases we revealed ESBL-producing strains using double-disk method. ESBL-producing strains expressed gene of CTX-M-1-related enzymes in 93% and gene of CTX-M-9-related enzymes in 6.8% cases. We revealed 10 cases of colonization GIT by carbapenem-resistant Enterobacteriaceae which expressed gene CTX–M-1- related enzymes (8 strains) and gene OXA-48 (2 strains). Detection of carbapenemase-producing K. pneumoniae was demonstrated the need of the strictest compliance with infection control measures and the introduction of modern methods of microbiological diagnosis.

Keywords

• enterobacteriaceae
• escherichia coli
• klebsiella pneumoniae
• colonisation
• antimicrobial resistance
• esbl
• carbapenemases