Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Yoshiharu Muto; Masaaki Nishiyama; Akihiro Nita; Toshiro Moroishi; Keiichi I. Nakayama

doi:10.1038/ncomms16114

Nature Communications (Jul 2017)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Yoshiharu Muto,
Masaaki Nishiyama,
Akihiro Nita,
Toshiro Moroishi,
Keiichi I. Nakayama

Affiliations

Yoshiharu Muto: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Masaaki Nishiyama: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Akihiro Nita: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Toshiro Moroishi: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University
Keiichi I. Nakayama: Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University

DOI: https://doi.org/10.1038/ncomms16114
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

The iron-regulated F-box protein FBXL5 regulates iron homeostasis by mediating the degradation of iron regulatory protein 2 (IRP2). Here the authors show that FBXL5 and its regulation of IRP2 are required for HSC self-renewal and reconstitution capability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal