LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step

Katrina B. Mar; Nicholas R. Rinkenberger; Ian N. Boys; Jennifer L. Eitson; Matthew B. McDougal; R. Blake Richardson; John W. Schoggins

doi:10.1038/s41467-018-06000-y

Nature Communications (Sep 2018)

LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step

Katrina B. Mar,
Nicholas R. Rinkenberger,
Ian N. Boys,
Jennifer L. Eitson,
Matthew B. McDougal,
R. Blake Richardson,
John W. Schoggins

Affiliations

Katrina B. Mar: Department of Microbiology, University of Texas Southwestern Medical Center
Nicholas R. Rinkenberger: Department of Microbiology, University of Texas Southwestern Medical Center
Ian N. Boys: Department of Microbiology, University of Texas Southwestern Medical Center
Jennifer L. Eitson: Department of Microbiology, University of Texas Southwestern Medical Center
Matthew B. McDougal: Department of Microbiology, University of Texas Southwestern Medical Center
R. Blake Richardson: Department of Microbiology, University of Texas Southwestern Medical Center
John W. Schoggins: Department of Microbiology, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-018-06000-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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The interferon-induced gene LY6E increases virus infection, but the underlying mechanism is poorly understood. Here, Mar et al. show that LY6E enhances uncoating of influenza A virus after endosomal escape and that viral enhancement by LY6E is conserved across evolution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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