G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Thian-Sze Wong; Guangzhi Li; Shiliang Li; Wei Gao; Geng Chen; Shiyi Gan; Manzhan Zhang; Honglin Li; Song Wu; Yang Du

doi:10.1038/s41392-023-01427-2

Signal Transduction and Targeted Therapy (May 2023)

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders

Thian-Sze Wong,
Guangzhi Li,
Shiliang Li,
Wei Gao,
Geng Chen,
Shiyi Gan,
Manzhan Zhang,
Honglin Li,
Song Wu,
Yang Du

Affiliations

Thian-Sze Wong: Kobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong
Guangzhi Li: Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University
Shiliang Li: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
Wei Gao: Kobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong
Geng Chen: Kobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong
Shiyi Gan: Kobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong
Manzhan Zhang: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
Honglin Li: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
Song Wu: Institute of Urology, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University
Yang Du: Kobilka Institute of Innovative Drug Discovery, Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Medicine, The Chinese University of Hong Kong

DOI: https://doi.org/10.1038/s41392-023-01427-2
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 57

Abstract

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Abstract Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the diseases are resulting from heterogeneous biological, genetic, and environmental factors. Nevertheless, the increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge of molecular mechanisms and structural information of GPCRs will be advantageous for developing effective drugs. This review provides an overview of the role of GPCRs in various neurodegenerative and psychiatric diseases. Besides, we highlight the emerging opportunities of novel GPCR targets and address recent progress in GPCR drug development.

Published in Signal Transduction and Targeted Therapy

ISSN: 2059-3635 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General)
Website: http://www.nature.com/sigtrans/

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