In vitro study: binding of 99mTc-DPD to synthetic amyloid fibrils

Abstract

This paper is an report of the investigation of the in vitro binding of 99mTc-DPD for synthetic amyloid fibrils used for the diagnosis of cardiac amyloidosis (CA), as compared with the use of 99mTc-HMDP and 99mTc-PPI. It also includes an inquiry into the role played by Ca2+ ions and serum proteins on binding to amyloid like materials, as well as the saturability and specificity of DPD for fibrils versus amorphous precipitates (AP).

Keywords

• nuclear medicine imaging
• cardiac amyloidosis
• 99mtc-diphosphonates
• amyloid synthetic fibrils