The efficacy of nelfinavir and lopinavir/ritonavir in the treatment of HIV-infected pediatric patients

Abstract

Objective: to characterize the efcacy of nelfnavir and lopinavir/ritonavir in the starting regimens of antiretroviral therapy for HIV-infected pediatric patients.Materials and methods: 50 HIV-infected patients aged 24-36 months were treated with abacavir and lamivudine in combination with nelfnavir (24 children) or lopinavir/ritonavir (26 patients).Results: Using both antiretroviral therapy schemes leads to suppression of HIV replication, improvement of clinical and immunological parameters. However, the treatment with lopinavir/ritonavir revealed a signifcant positive changes of HIV blood viral load, immune status and clinical picture. With the help of mathematical modeling, the signifcance of lopinavir/ritonavir appointment as an independent predictor of effectiveness prolongation of antiretroviral therapy has been proved. As a side effect of lopinavir/ritonavir developed dyspeptic symptoms.Conclusion: Te results of the study indicate the high efcacy and safety of lopinavir/ritonavir use compared to nelfnavir in HIV-infected pediatric patients.

Keywords

• hiv infection
• lopinavir/ritonavir
• nelfnavir