Elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular docking

Abstract

Objective: To investigate the mechanism of Renshen Guben oral liquid (RSGB) enhancing immune function. Materials and Methods: Network pharmacology and molecular docking were used to intuitively demonstrate the mechanism of immune regulation of RSGB. Results: A total of 112 active compounds of RSGB were found, and 501 targets were predicted. Furthermore, 2974 immune targets were obtained from UniProt and NCBI Gene databases, and 111 common targets of RSGB and immunity were obtained. Among them, interleukin (IL) 6, tumor necrosis factor, AKT1, VEGFA, STAT3, MAPK1, SRC, EGFR, IL1B, and PTGS2 might be the key targets for RSGB to improve immunity. ClueGO and Kyoto Encyclopedia of Genes and Genomes analysis showed that the immunoregulatory mechanism of RSGB may find a relation with the B cell receptor signaling pathway and T cell receptor signaling pathway. Furthermore, this study preliminarily explored the mechanism of RSGB improving menopausal syndrome, polycystic ovary syndrome, and cancer-related fatigue by enhancing immunity. Conclusions: RSGB can improve the body's immunity through multicomponent, multitarget, and multipathway. In addition, RSGB can also improve the immune capacity of the body to assist in the treatment of diseases, which has great potential as an immunomodulator.

Keywords

• immunity
• molecular docking
• network pharmacology
• renshen guben oral liquid