FREQUENCY OF INHERITED THROMBOPHILIA GENE POLYMORPHISM IN WOMEN WITH REPRODUCTIVE HEALTH DISORDERS

Abstract

This article analyzes the frequency of polymorphisms of hemostasis system and folate cycle protein genes associated with increased risk of thrombophilia based on the results of CHGMA (Chita State Medical Academy) genetic laboratory patients with reproductive health disorders. Method of research is allele-specific PCR. It was analyzed 1800 DNA samples. The most frequently mutations occur in the genes of receptors in the platelets and the folate cycle, mostly heterozygous substitution. Leiden mutation (F5) and prothrombin mutation (F2) are the most significant in the thrombophilia development and occur much less frequently. Only in one case revealed a homozygous mutation in the gene F2 and F5.

Keywords

• inherited thrombophilia
• hemostasis system genes
• folate cycle protein genes