Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer

Abstract

The intermediate states of the epithelial-to-mesenchymal transition (EMT) in cancer require further molecular characterisation. Here, the authors develop a method to evaluate EMT transformation and trajectories in cancer transcriptomics data, characterising EMT macro-states, including a hybrid state, and EMT hallmarks.