The combination therapy in arterial hypertension: opportunities of the fixed combination of irbesartan andhydrochlorothiazide(Koaprovel’)

Abstract

The article deals with the various aspects of the combinationtherapyin arterial hypertension. We showed the complementary effects and benefits of the combination of angiotensin II receptor antagonistsand diuretics; also we described clinical caseswhere thiscombination therapy is forpriority use. In detail we analysed the literature data on the efficacy and safety of combination of irbesartan and hydrochlorothiazide, including long-term use.

Keywords

• arterial hypertension
• fixed combination
• angiotensin ii receptor antagonists
• irbesartan
• diuretics
• hydrochlorothiazide