Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors

Xiaopin Duan; Christina Chan; Wenbo Han; Nining Guo; Ralph R. Weichselbaum; Wenbin Lin

doi:10.1038/s41467-019-09221-x

Nature Communications (Apr 2019)

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors

Xiaopin Duan,
Christina Chan,
Wenbo Han,
Nining Guo,
Ralph R. Weichselbaum,
Wenbin Lin

Affiliations

Xiaopin Duan: Department of Chemistry, The University of Chicago
Christina Chan: Department of Chemistry, The University of Chicago
Wenbo Han: Department of Chemistry, The University of Chicago
Nining Guo: Department of Chemistry, The University of Chicago
Ralph R. Weichselbaum: Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago
Wenbin Lin: Department of Chemistry, The University of Chicago

DOI: https://doi.org/10.1038/s41467-019-09221-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Nanoparticles can stimulate tumour microenvironment to promote anti-tumour immunity. Here, the authors show that the combination of delivering drugs by a nanoscale coordination polymer and anti-PD-L1 is synergistic in treating murine colorectal cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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