THE ROLE OF LASER DOPPLER FLOWMETRY IN THE STUDY OF SKIN MICROCIRCULATION IN DIFFUSE LIVER DISEASES

Abstract

Among the most important links in the pathogenesis of diffuse liver diseases (DLD) are macro- and microhemodynamic disorders that can develop in the liver and in the systemic circulation [2, 3, 7, 12]. Chronic hepatitis (CH) and especially liver cirrhosis (LC) are accompanied by disorders of the portal and systemic circulation, development of portal hypertension which leads to the emergence of portosystemic collaterals and hyperdynamic circulation [2, 3, 7, 12]. The resulting rheological changes in the blood, disorders of systemic hemodynamics run in parallel with the microcirculatory (MC) pathology. [8, 9, 12] In this condition, the inflammatory and reparative processes, maintainance of the adequate level of biochemical reactions in the tissues, cellular functions and changes in blood coagulation system are determined by the microcirculation (MC) status [2, 3, 12].

Keywords

• diffuse liver disease
• chronic hepatitis
• liver cirrhosis
• laser doppler flowmetry