Open Life Sciences (Nov 2023)
Exploring the conformational dynamics and thermodynamics of EGFR S768I and G719X + S768I mutations in non-small cell lung cancer: An in silico approaches
- Wang Jun-Ling,
- Liu Ming-Sheng,
- Fu Yu-Dong,
- Kan Qiang-Bo,
- Li Chun-Yan,
- Ma Rong,
- Fang Zhe-Wei,
- Liu Hong-Xia,
- Li Meng-Xian,
- Lv Jia-Ling,
- Sang Peng,
- Zhang Chao,
- Li Hong-Wei
Affiliations
- Wang Jun-Ling
- Clinical Laboratory, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Liu Ming-Sheng
- Department of Urological Surgery, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Fu Yu-Dong
- Department of Thoracic Surgery, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Kan Qiang-Bo
- Department of Thoracic Surgery, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Li Chun-Yan
- Department of Oncology, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Ma Rong
- Clinical Laboratory, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Fang Zhe-Wei
- Clinical Laboratory, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Liu Hong-Xia
- Clinical Laboratory, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Li Meng-Xian
- Clinical Laboratory, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Lv Jia-Ling
- Department of Oncology, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Sang Peng
- School of Life Science, Dali University, Dali671003, China
- Zhang Chao
- Department of Oncology, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- Li Hong-Wei
- Clinical Laboratory, Kunming Medical University Affiliated Qujing Hospital, Qujing655000, China
- DOI
- https://doi.org/10.1515/biol-2022-0768
- Journal volume & issue
-
Vol. 18,
no. 1
pp. 1 – 20
Abstract
No abstracts available.Keywords
- epidermal growth factor receptor g719x and s768i mutations
- non-small cell lung cancer
- molecular dynamics simulation
- conformation
- free energy landscape