Zhongguo cuzhong zazhi (Sep 2018)
缺血性卒中患者颈动脉斑块与内皮素-1及丙二醛水平的相关性分析 Correlation of Endothelin-1 and Malondialdehyde with Carotid Plaques in Patients with Ischemic Stroke
Abstract
目的 探讨急性缺血性卒中患者颈动脉粥样硬化斑块与血浆内皮素-1（endothelin-1，ET-1）及丙二醛 （malondialdehyde，MDA）水平的关系。 方法 118例急性缺血性卒中患者均行颈动脉超声检查，分为动脉内膜正常组（12例）、动脉内膜 增厚组（28例）及动脉斑块组（78例）；并将斑块组分为I级斑块（21例）、II级斑块（25例）、III级斑块 （32例）。测定各组患者血浆ET-1及MDA水平，并进行统计分析。 结果 内膜正常组、内膜增厚组和斑块组血浆ET-1水平分别为（2.34±0.27）ng/L、（3.96±0.38）ng/L和 （6.23±0.42）ng/L；MDA水平分别为（4.20±0.48）nmol/ml、（6.18±0.52）nmol/ml和（8.37±0.65）nmol/ml。斑 块组及内膜增厚组患者血浆ET-1（P =0.036，P =0.031）及MDA（P =0.046，P =0.022）水平均高于内膜正 常组，差异有统计学意义；斑块组血浆ET-1（P =0.040）及MDA（P =0.034）水平高于内膜增厚组，差异 有统计学意义。斑块组血浆ET-1（P =0.041）及MDA（P =0.037）水平随着斑块的严重程度而增加 。 结论 血浆ET-1及MDA水平与急性缺血性卒中患者颈动脉粥样硬化及其严重程度有关。 Abstract: Objective To investigate the correlation between carotid plaques and endothelin-1 (ET-1) and malondialdehyde (MDA) in patients with acute ischemic stroke. Methods Carotid ultrasonography was performed in 118 patients with acute ischemic stroke. All patients were divided into normal intima group (n =12), intima thickening group (n =28) and plaque group (n =78). The plaque group was divided into plaque I (n =21), plaque II (n =25) and plaque III (n =32). The plasma ET-1 and MDA level were measured in each group. The correlation of ET-1 and MDA with plaque formation was analyzed. Results The level of plasma ET-1 in normal, thickening intima and plaque groups were (2.34±0.27) ng/L, (3.96±0.38) ng/L and (6.23±0.42) ng/L, respectively; and the level of plasma MDA in the three groups were (4.20±0.48) nmol/ml, (6.18±0.52) nmol/ml and (8.37±0.65) nmol/ml, respectively. The level of plasma ET-1 (P =0.036, P =0.031) and MDA (P =0.046, P =0.022) in plaque group and intima thickening group were significantly higher than that in normal intima group; and both ET-1 and MDA in plaque group were higher than that in intima thickening group (P =0.040, P =0.034). With the severity of plaque increasing, the plasma ET-1 and MDA levels gradually increased (P =0.041, P =0.037). Conclusion Plasma ET-1 and MDA levels are associated with carotid atherosclerosis and its severity in patients with acute ischemic stroke.
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