Objective: To measure the quality of the transition of care for COVID-19 patients after discharge from hospital to home. Method: A cross-sectional, prospective study carried out in a hospital in Santa Catarina, with 201 patients hospitalized for COVID-19. An instrument was used to characterize the patients and the Brazilian version of the Care Transitions Measure. The data were analyzed using descriptive statistics, represented by absolute and relative frequency, and Cronbach’s alpha and parametric tests were used, including the t-test, considering statistical significance at p < 0.05. Results: There was a predominance of male patients (55.2%), with a mean age of 22.2 years (SD = 9.9), 79.6% white, and 60.2% married or in a stable union. The overall mean of the CTM-15 was 52.97, with the highest mean observed in the preparation for self-management factor (58.31) and the lowest in the care plan factor (34.00). Conclusion: The quality of the transition of care for patients hospitalized due to COVID-19 was unsatisfactory.