Cancer Management and Research (Mar 2020)
LncRNA MORT Inhibits Cancer Cell Proliferation and Promotes Apoptosis in Mantle Cell Lymphoma by Upregulating miRNA-16
Abstract
Xiaoqiong Tang, Yaoying Long, Liuyue Xu, Xinyu Yan Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing City 400016, People’s Republic of ChinaCorrespondence: Xiaoqiong TangDepartment of Hematology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, YuZhong District, Chongqing City 400016, People’s Republic of ChinaTel +86 23-89011508Email [email protected]: LncRNA mortal obligate RNA transcript (MORT) is downregulated in different types of cancer, indicating its involvement in cancer biology.Methods: In this study, MORT and miRNA-16 were both downregulated in plasma of mantle cell lymphoma (MCL) patients than that in the controls. The low levels of MORT and miRNA-16 were correlated with poor survival of MCL patients. The expression of MORT and miRNA-16 was positively correlated only in MCL patients.Results: Overexpression of MORT and miRNA-16 suppressed cell proliferation but promoted cancer cell apoptosis, while miRNA-16 inhibitor reduced the effects of MORT overexpression. Overexpression of MORT led to upregulated expression of miRNA-16, while overexpression of miRNA-16 had no effect on the expression of MORT.Conclusion: Therefore, MORT may inhibit cancer cell proliferation and promote apoptosis in mantle cell lymphoma by upregulating miRNA-16.Keywords: mantle cell lymphoma, MORT, miRNA-16, prognosis, cancer cell
