BAG5 regulates PTEN stability in MCF-7 cell line

Abstract

The phosphatase and tensin homolog deleted on chromosome10 (PTEN) is a tumor-suppressing lipid phosphatase that isfrequently absent in breast tumors. Thus, the stability of PTENis essential for tumor prevention and therapy. The ubiquitinproteasomepathway has an important role in regulating thefunctions of PTEN. Specifically, carboxyl terminus Hsp70-interacting protein (CHIP), the E3 ubiquitin ligase of PTEN, canregulate PTEN levels. In this study, we report that BCL-2-associated athanogene 5 (BAG5), a known inhibitor of CHIPactivity, reduces the degradation of PTEN and maintains itslevels via an ubiquitylation-dependent pathway. BAG5 isidentified as an antagonist of cell tumorigenicity. [BMBReports 2013; 46(10): 490-494]

Keywords

• BAG5
• CHIP
• PTEN
• Ubiquitin
• Ubiquitination