Zdorovʹe Rebenka (Oct 2012)

Molecular and Genetic Basics and Strategy of Bronchial Asthma Analysis in Children

  • L.Ya. Lytvynets,
  • O.B. Synoverska,
  • O.Z. Gnateyko,
  • N.V. Vyshtak

DOI
https://doi.org/10.22141/2224-0551.0.7.42.2012.193645
Journal volume & issue
Vol. 0, no. 7.42
pp. 85 – 89

Abstract

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The phenotype features of bronchial asthma (BA) in 94 children from the Ivano-Frankivsk region with different types of the allelic polymorphism of microsomal epoxide hydrolase gene 1 (mEPXH 1) have been studied. The association between the polymorphism of mEPXH 1 gene and predisposition to appearance and severity of asthma in children has been described. It is found that individual types of metabolic activity of xenobiotic detoxification genes influence the BA realization. It’s proved that СС and GG (p < 0.05) genotypes of BA were noticed more frequently in patients with uncontrolled bronchial asthma. High enzyme activity of mEPHX 1 gene (polymorphic AG-TT and AA-TT types) is more often observed in children with BA. Slow allele of mEPHX 1 gene responding to variants of homo- and heterozygotes by mutant alleles CC-AA and TC-AA is quite often.

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