Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

Tripathi Mamta; Asatkar Ashish Kumar; Antony Stalin; Dash Mrinal Kanti; Roymahapatra Gourisankar; Pande Rama; Sarkar Avijit; Aldakheel Fahad M.; Binshaya Abdulkarim S.; Alharthi Nahed S.; Alaofi Ahmed L.; Alqahtani Mohammed S.; Syed Rabbani

doi:10.1515/chem-2022-0164

Open Chemistry (Jun 2022)

Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies

Tripathi Mamta,
Asatkar Ashish Kumar,
Antony Stalin,
Dash Mrinal Kanti,
Roymahapatra Gourisankar,
Pande Rama,
Sarkar Avijit,
Aldakheel Fahad M.,
Binshaya Abdulkarim S.,
Alharthi Nahed S.,
Alaofi Ahmed L.,
Alqahtani Mohammed S.,
Syed Rabbani

Affiliations

Tripathi Mamta: School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, 492010, Chhattisgarh, India
Asatkar Ashish Kumar: Department of Chemistry, Government Gundadhur P. G. College, Kondagaon, 494226, Chhattisgarh, India
Antony Stalin: Department of Traditional Chinese Medicine, State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, 311300, China
Dash Mrinal Kanti: Department of Applied Sciences, Haldia Institute of Technology, Haldia, 721657, India
Roymahapatra Gourisankar: Department of Applied Sciences, Haldia Institute of Technology, Haldia, 721657, India
Pande Rama: School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, 492010, Chhattisgarh, India
Sarkar Avijit: Department of Chemistry, Bhairab Ganguly College, Belghoria, Kolkata, 700056, India
Aldakheel Fahad M.: Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11433, Saudi Arabia
Binshaya Abdulkarim S.: Department of Medical Laboratory Sciences, College of Medical Sciences, Prince Sattam bin Abdulaziz University (PSAU), Alkharz, Saudi Arabia
Alharthi Nahed S.: Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University (PSAU), Alkharj, Saudi Arabia
Alaofi Ahmed L.: Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O Box. 2457, Riyadh, 11451, Kingdom of Saudi Arabia
Alqahtani Mohammed S.: Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O Box. 2457, Riyadh, 11451, Kingdom of Saudi Arabia
Syed Rabbani: Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O Box. 2457, Riyadh, 11451, Kingdom of Saudi Arabia

DOI: https://doi.org/10.1515/chem-2022-0164
Journal volume & issue: Vol. 20, no. 1
pp. 505 – 516

Abstract

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Two new copper(ii) complexes [CuL1] (1) and [CuL2] (2) derived from azo-based ligands 2-hydroxy-5-p-tolylazo-benzaldehyde (HL1) and 1-(2-hydroxy-5-p-tolylazo-phenyl)-ethan-one (HL2) were synthesized. These two ligands and their metal complexes were characterized by elemental analysis, nuclear magnetic resonance (1H and 13C), infrared, and UV/Vis spectroscopic techniques. Spectroscopy and other theoretical studies reveal the geometry of copper complexes, and their binding affinity towards nucleic acids are major groove binding.

Published in Open Chemistry

ISSN: 2391-5420 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Chemistry
Website: https://www.degruyter.com/journal/key/CHEM/html

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