P454: VENETOCLAX AND GILTERITINIB SYNERGIZE IN FLT3 WILDTYPE ACUTE MYELOID LEUKEMIA BY SUPPRESSION OF MCL-1 VIA COMBINED AXL AND FLT3 TARGETING

• C. Schmidt,
• M. Janssen,
• P.-M. Bruch,
• M. F. Blank,
• C. Rohde,
• A. Waclawiczek,
• S. Renders,
• D. Heid,
• S. Göllner,
• L. Vierbaum,
• K. Weidenauer,
• S. Herbst,
• M. Knoll,
• C. Kolb,
• B. Besenbeck,
• M. Fabre,
• M. Gu,
• R. Schlenk,
• F. Stölzel,
• M. Bornhäuser,
• C. Röllig,
• U. Platzbecker,
• C. Baldus,
• H. Serve,
• T. Sauer,
• S. Raffel,
• C. Pabst,
• G. Vassiliou,
• B. Vick,
• I. Jeremias,
• A. Trumpp,
• J. Krijgsveld,
• C. Müller-Tidow,
• S. Dietrich

Affiliations

C. Schmidt

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

M. Janssen

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

P.-M. Bruch

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

M. F. Blank

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

C. Rohde

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

A. Waclawiczek

4 Division of Stem Cells and Cancer, German Cancer Research Centre (DKFZ), Heidelberg, Germany

S. Renders

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

D. Heid

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

S. Göllner

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

L. Vierbaum

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

K. Weidenauer

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

S. Herbst

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

M. Knoll

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

C. Kolb

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

B. Besenbeck

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

M. Fabre

5 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton

M. Gu

5 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton

R. Schlenk

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

F. Stölzel

7 Department of Medicine I, University hospital Carl Gustav Carus, Dresden

M. Bornhäuser

7 Department of Medicine I, University hospital Carl Gustav Carus, Dresden

C. Röllig

7 Department of Medicine I, University hospital Carl Gustav Carus, Dresden

U. Platzbecker

8 Medical Clinic and Policlinic I, Hematology and Cellular Therapy, Leipzig University Hospital, Leipzig

C. Baldus

9 Department of Hematology and Oncology, University hospital Schleswig-Holstein, Campus Kiel, Kiel

H. Serve

10 Department of Medicine II, Hematology-Oncology, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany

T. Sauer

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

S. Raffel

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

C. Pabst

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

G. Vassiliou

5 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton

B. Vick

12 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München

I. Jeremias

12 Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München

A. Trumpp

4 Division of Stem Cells and Cancer, German Cancer Research Centre (DKFZ), Heidelberg, Germany

J. Krijgsveld

3 Division Proteomics of Stem Cells and Cancer

C. Müller-Tidow

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg

S. Dietrich

1 Department of Medicine V, Hematology, Oncology and Rheumatology, University hospital Heidelberg