Biotechnological Approaches on Engineering Medicinal Tropane Alkaloid Production in Plants

Haiyue Gong; Ping He; Xiaozhong Lan; Lingjiang Zeng; Zhihua Liao; Zhihua Liao

doi:10.3389/fpls.2022.924413

Frontiers in Plant Science (Jun 2022)

Biotechnological Approaches on Engineering Medicinal Tropane Alkaloid Production in Plants

Haiyue Gong,
Ping He,
Xiaozhong Lan,
Lingjiang Zeng,
Zhihua Liao,
Zhihua Liao

Affiliations

Haiyue Gong: School of Life Sciences, Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, The Provincial and Ministerial Co-founded Collaborative Innovation Center for R&D in Tibet Characteristic Agricultural and Animal Husbandry Resources, Southwest University, Chongqing, China
Ping He: Chongqing Academy of Science and Technology, Chongqing, China
Xiaozhong Lan: Xizang Agricultural and Husbandry College, The Provincial and Ministerial Co-founded Collaborative Innovation Center for R&D in Tibet Characteristic Agricultural and Animal Husbandry Resources, The Center for Xizang Chinese (Tibetan) Medicine Resource, TAAHC-SWU Medicinal Plant Joint R&D Centre, Nyingchi, China
Lingjiang Zeng: School of Life Sciences, Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, The Provincial and Ministerial Co-founded Collaborative Innovation Center for R&D in Tibet Characteristic Agricultural and Animal Husbandry Resources, Southwest University, Chongqing, China
Zhihua Liao: School of Life Sciences, Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, The Provincial and Ministerial Co-founded Collaborative Innovation Center for R&D in Tibet Characteristic Agricultural and Animal Husbandry Resources, Southwest University, Chongqing, China
Zhihua Liao: Chongqing Academy of Science and Technology, Chongqing, China

DOI: https://doi.org/10.3389/fpls.2022.924413
Journal volume & issue: Vol. 13

Abstract

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Hyoscyamine and scopolamine, belonging to medicinal tropane alkaloids (MTAs), are potent anticholinergic drugs. Their industrial production relies on medicinal plants, but the levels of the two alkaloids are very low in planta. Engineering the MTA’s production is an everlasting hot topic for pharmaceutical industry. With understanding the MTA’s biosynthesis, biotechnological approaches are established to produce hyoscyamine and scopolamine in an efficient manner. Great advances have been obtained in engineering MTA’s production in planta. In this review, we summarize the advances on the biosynthesis of MTAs and engineering the MTA’s production in hairy root cultures, as well in plants. The problems and perspectives on engineering the MTA’s production are also discussed.

Published in Frontiers in Plant Science

ISSN: 1664-462X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Agriculture: Plant culture
Website: https://www.frontiersin.org/journals/plant-science

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