Giant Multinucleated Cells in Aging and Senescence—An Abridgement
Malgorzata Kloc,
Ahmed Uosef,
Arijita Subuddhi,
Jacek Z. Kubiak,
Rafal P. Piprek,
Rafik M. Ghobrial
Affiliations
Malgorzata Kloc
The Houston Methodist Research Institute, Transplant Immunology, Houston, TX 77030, USA
Ahmed Uosef
The Houston Methodist Research Institute, Transplant Immunology, Houston, TX 77030, USA
Arijita Subuddhi
The Houston Methodist Research Institute, Transplant Immunology, Houston, TX 77030, USA
Jacek Z. Kubiak
Dynamics and Mechanics of Epithelia Group, Faculty of Medicine, Institute of Genetics and Development of Rennes, University of Rennes, CNRS, UMR 6290, 35043 Rennes, France
Rafal P. Piprek
Department of Comparative Anatomy, Institute of Zoology and Biomedical Research, Jagiellonian University, 30-387 Krakow, Poland
Rafik M. Ghobrial
The Houston Methodist Research Institute, Transplant Immunology, Houston, TX 77030, USA
This review introduces the subject of senescence, aging, and the formation of senescent multinucleated giant cells. We define senescence and aging and describe how molecular and cellular senescence leads to organismal senescence. We review the latest information on senescent cells’ cellular and molecular phenotypes. We describe molecular and cellular features of aging and senescence and the role of multinucleated giant cells in aging-related conditions and cancer. We explain how multinucleated giant cells form and their role in aging arteries and gonads. We also describe how multinucleated giant cells and the reversibility of senescence initiate cancer and lead to cancer progression and metastasis. We also describe molecules and pathways regulating aging and senescence in model systems and their applicability to clinical therapies in age-related diseases.
