Southern African Journal of HIV Medicine (Jun 2012)

Levels of procalcitonin, C-reactive protein and neopterin in patients with advanced HIV-1 infection

  • P Bipath,
  • M Viljoen,
  • Peter F Levay

DOI
https://doi.org/10.4102/sajhivmed.v13i2.143
Journal volume & issue
Vol. 13, no. 2
pp. 78 – 82

Abstract

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Objectives. To compare the value of procalcitonin, C-reactive protein (CRP) and neopterin as indicators of immune deficiency, co-infection, efficacy of treatment, and disease progression, in patients with advanced HIV-1 infection. Design. Cross-sectional, investigating baseline blood measurements and clinical observations in 82 HIV-positive patients divided into an antiretroviral treatment (ART) group and an ART-naïve group. Setting. Secondary general hospital in Pretoria. Results. Procalcitonin and CRP levels showed no significant differences between the ART and ART-naïve groups, and no correlations with CD4 counts or viral loads. CRP levels were significantly higher with TB co-infection (p