Nature Communications (May 2018)
Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure
- Alessia Visconti,
- David L. Duffy,
- Fan Liu,
- Gu Zhu,
- Wenting Wu,
- Yan Chen,
- Pirro G. Hysi,
- Changqing Zeng,
- Marianna Sanna,
- Mark M. Iles,
- Peter A. Kanetsky,
- Florence Demenais,
- Merel A. Hamer,
- Andre G. Uitterlinden,
- M. Arfan Ikram,
- Tamar Nijsten,
- Nicholas G. Martin,
- Manfred Kayser,
- Tim D. Spector,
- Jiali Han,
- Veronique Bataille,
- Mario Falchi
Affiliations
- Alessia Visconti
- Department of Twin Research and Genetic Epidemiology, King’s College London
- David L. Duffy
- QIMR Berghofer Medical Research Institute
- Fan Liu
- CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
- Gu Zhu
- QIMR Berghofer Medical Research Institute
- Wenting Wu
- Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
- Yan Chen
- CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
- Pirro G. Hysi
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Changqing Zeng
- CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences
- Marianna Sanna
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Mark M. Iles
- Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds
- Peter A. Kanetsky
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute
- Florence Demenais
- INSERM, UMR 946, Genetic Variation and Human Diseases Unit
- Merel A. Hamer
- Department of Dermatology, Erasmus MC University Medical Center Rotterdam
- Andre G. Uitterlinden
- Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam
- M. Arfan Ikram
- Department of Epidemiology, Erasmus MC University Medical Center Rotterdam
- Tamar Nijsten
- Department of Dermatology, Erasmus MC University Medical Center Rotterdam
- Nicholas G. Martin
- QIMR Berghofer Medical Research Institute
- Manfred Kayser
- Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam
- Tim D. Spector
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Jiali Han
- Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
- Veronique Bataille
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Mario Falchi
- Department of Twin Research and Genetic Epidemiology, King’s College London
- DOI
- https://doi.org/10.1038/s41467-018-04086-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 7
Abstract
The skin’s tanning response to sun exposure shows great interindividual variability. Here, Visconti et al. perform a genome-wide association study for ease of skin tanning and identify 20 genetic loci, ten of which had not previously been associated with pigmentation-related traits.
