Sensing and responding to allergic response cytokines through a genetically encoded circuit

Hélène Chassin; Barbara Geering; Lina Schukur; David Ausländer; Brian Lang; Martin Fussenegger

doi:10.1038/s41467-017-01211-1

Nature Communications (Oct 2017)

Sensing and responding to allergic response cytokines through a genetically encoded circuit

Hélène Chassin,
Barbara Geering,
Lina Schukur,
David Ausländer,
Brian Lang,
Martin Fussenegger

Affiliations

Hélène Chassin: Department of Biosystems Science and Engineering, ETH Zürich
Barbara Geering: Department of Biosystems Science and Engineering, ETH Zürich
Lina Schukur: Department of Biosystems Science and Engineering, ETH Zürich
David Ausländer: Department of Biosystems Science and Engineering, ETH Zürich
Brian Lang: Department of Biosystems Science and Engineering, ETH Zürich
Martin Fussenegger: Department of Biosystems Science and Engineering, ETH Zürich

DOI: https://doi.org/10.1038/s41467-017-01211-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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The standard treatment for an allergic response is anti-histamines, steroids and anti-IgE antibodies. Here the authors present a genetic circuit that senses IL-4 and IL-13 and responses with DARPin production to bind IgE.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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