Role of Hematological Parameters in Systemic Sclerosis Patients with Pulmonary System Involvement

Abstract

Aim: Systemic sclerosis (SSc) is an autoimmune disease characterized by generalized micro and macroangiopathy. Mortality in SSc is primarily due to pulmonary complications. This study was aimed to reveal the relationship between parenchymal and vascular involvements of the pulmonary system and hematological parameters in patients with SSc. Material and Method: Participants were divided into three groups: both interstitial lung disease (ILD) and pulmonary hypertension (PH), those with only ILD and those with neither ILD nor PH. Laboratory data were compared between these groups. Results: ILD was found to be associated with high red cell distribution width (RDW) and erythrocyte sedimentation rate, independent of PH. The platelet (PLT) count was significantly lower, and the RDW to PLT ratio (RPR) level was significantly higher in those with ILD and PH coexistence compared to those with only ILD. Conclusion: RPR can be used as screening parameters for PH in ILD associated with SSc.

Keywords

• interstitial lung disease
• pulmonary hypertension
• systemic sclerosis
• interstisyel akciğer hastalığı
• pulmoner hipertansiyon
• sistemik skleroz