Nature Communications (Jun 2017)
Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity
- Meng Xia,
- Juan Liu,
- Shuxun Liu,
- Kun Chen,
- Hongyu Lin,
- Minghong Jiang,
- Xiaoqing Xu,
- Yiquan Xue,
- Wei Liu,
- Yan Gu,
- Xiang Zhang,
- Zhiqing Li,
- Lin Yi,
- Youcun Qian,
- Chen Zhou,
- Ru Li,
- Xuan Zhang,
- Zhanguo Li,
- Xuetao Cao
Affiliations
- Meng Xia
- Department of Immunology & Center for Immunotherapy, National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
- Juan Liu
- National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
- Shuxun Liu
- National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
- Kun Chen
- Institute of Immunology, Zhejiang University School of Medicine
- Hongyu Lin
- Institute of Immunology, Zhejiang University School of Medicine
- Minghong Jiang
- Department of Immunology & Center for Immunotherapy, National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
- Xiaoqing Xu
- Department of Immunology & Center for Immunotherapy, National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
- Yiquan Xue
- National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
- Wei Liu
- Department of Immunology & Center for Immunotherapy, National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
- Yan Gu
- National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
- Xiang Zhang
- National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
- Zhiqing Li
- Institute of Immunology, Zhejiang University School of Medicine
- Lin Yi
- National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
- Youcun Qian
- Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Chen Zhou
- Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
- Ru Li
- Department of Rheumatology & Immunology, Peking University People’s Hospital
- Xuan Zhang
- Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
- Zhanguo Li
- Department of Rheumatology & Immunology, Peking University People’s Hospital
- Xuetao Cao
- Department of Immunology & Center for Immunotherapy, National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
- DOI
- https://doi.org/10.1038/ncomms15818
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
The transcriptional program activated by Smad2/Smad3 is critical for the induction and function of regulatory T cells. Here the authors show that the expression of Smad3 is modulated by the complementary functions of a methyltransferase Ash1l and an lncRNA lnc-Smad3 on the promoter accessibility of the mouseSmad3locus.
