Whole-muscle fat analysis identifies distal muscle end as disease initiation site in facioscapulohumeral muscular dystrophy

Abstract

Heskamp et al. perform quantitative MRI analysis of end-to-end muscle fat fractions in a series of patients with facioscapulohumeral dystrophy. The authors report that disease initiation commonly occurs at the distal end of affected muscles, with wave-like progression to the proximal end.