Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development

Delfina M. Romero; Karine Poirier; Richard Belvindrah; Imane Moutkine; Anne Houllier; Anne-Gaëlle LeMoing; Florence Petit; Anne Boland; Stephan C. Collins; Mariano Soiza-Reilly; Binnaz Yalcin; Jamel Chelly; Jean-François Deleuze; Nadia Bahi-Buisson; Fiona Francis

doi:10.1038/s41467-022-30443-z

Nature Communications (May 2022)

Novel role of the synaptic scaffold protein Dlgap4 in ventricular surface integrity and neuronal migration during cortical development

Delfina M. Romero,
Karine Poirier,
Richard Belvindrah,
Imane Moutkine,
Anne Houllier,
Anne-Gaëlle LeMoing,
Florence Petit,
Anne Boland,
Stephan C. Collins,
Mariano Soiza-Reilly,
Binnaz Yalcin,
Jamel Chelly,
Jean-François Deleuze,
Nadia Bahi-Buisson,
Fiona Francis

Affiliations

Delfina M. Romero: INSERM UMR-S 1270
Karine Poirier: INSERM UMR-S 1163, Translational Genetics, Imagine Institute, Paris Cité University, Necker Enfants Malades University Hospital
Richard Belvindrah: INSERM UMR-S 1270
Imane Moutkine: INSERM UMR-S 1270
Anne Houllier: INSERM UMR-S 1270
Anne-Gaëlle LeMoing: Service of Pediatric Neurology, CHU Amiens
Florence Petit: Department of Clinical Genetics. Hôpital Jeanne de Flandre, CHU Lille
Anne Boland: National Center of Human Genomics Research (CNRGH), François Jacob Institute of Biology, CEA, University Paris-Saclay
Stephan C. Collins: INSERM UMR-S 1231, University of Bourgogne Franche-Comté
Mariano Soiza-Reilly: Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET, Universidad de Buenos Aires
Binnaz Yalcin: INSERM UMR-S 1231, University of Bourgogne Franche-Comté
Jamel Chelly: IGBMC-CNRS UMR-S 7104, INSERM UMR-S 964
Jean-François Deleuze: National Center of Human Genomics Research (CNRGH), François Jacob Institute of Biology, CEA, University Paris-Saclay
Nadia Bahi-Buisson: Laboratory of Genetics and Development of the Cerebral Cortex, INSERM UMR-S 1163, Imagine Institute
Fiona Francis: INSERM UMR-S 1270

DOI: https://doi.org/10.1038/s41467-022-30443-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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The Dlgap protein family members are known for their role in synapses. Here the authors reveal important involvement in earlier steps of brain development, identifying DLGAP4 mutations in patients with cortical malformations, and also demonstrating a role in progenitors and migrating neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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