Nature Communications (Sep 2019)
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
- Søs Grønbæk Holdgaard,
- Valentina Cianfanelli,
- Emanuela Pupo,
- Matteo Lambrughi,
- Michal Lubas,
- Julie C. Nielsen,
- Susana Eibes,
- Emiliano Maiani,
- Lea M. Harder,
- Nicole Wesch,
- Mads Møller Foged,
- Kenji Maeda,
- Francesca Nazio,
- Laura R. de la Ballina,
- Volker Dötsch,
- Andreas Brech,
- Lisa B. Frankel,
- Marja Jäättelä,
- Franco Locatelli,
- Marin Barisic,
- Jens S. Andersen,
- Simon Bekker-Jensen,
- Anders H. Lund,
- Vladimir V. Rogov,
- Elena Papaleo,
- Letizia Lanzetti,
- Daniela De Zio,
- Francesco Cecconi
Affiliations
- Søs Grønbæk Holdgaard
- Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Valentina Cianfanelli
- Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Emanuela Pupo
- Department of Oncology, University of Torino Medical School
- Matteo Lambrughi
- Computational Biology Laboratory, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Michal Lubas
- Biotech Research & Innovation Centre, University of Copenhagen
- Julie C. Nielsen
- Center for Healthy Aging, University of Copenhagen
- Susana Eibes
- Cell Division Laboratory, Danish Cancer Society Research Center
- Emiliano Maiani
- Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Lea M. Harder
- Department of Biochemistry and Molecular Biology, University of Southern Denmark
- Nicole Wesch
- Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University Frankfurt
- Mads Møller Foged
- Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Kenji Maeda
- Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Francesca Nazio
- Department of Pediatric Hemato-Oncology and Cell and Gene therapy, IRCCS Bambino Gesù Children’s Hospital
- Laura R. de la Ballina
- Department of Molecular Medicine, Institute of Basic Medical Sciences and Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
- Volker Dötsch
- Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University Frankfurt
- Andreas Brech
- Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital
- Lisa B. Frankel
- Biotech Research & Innovation Centre, University of Copenhagen
- Marja Jäättelä
- Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Franco Locatelli
- Department of Pediatric Hemato-Oncology and Cell and Gene therapy, IRCCS Bambino Gesù Children’s Hospital
- Marin Barisic
- Cell Division Laboratory, Danish Cancer Society Research Center
- Jens S. Andersen
- Department of Biochemistry and Molecular Biology, University of Southern Denmark
- Simon Bekker-Jensen
- Center for Healthy Aging, University of Copenhagen
- Anders H. Lund
- Biotech Research & Innovation Centre, University of Copenhagen
- Vladimir V. Rogov
- Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University Frankfurt
- Elena Papaleo
- Computational Biology Laboratory, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Letizia Lanzetti
- Department of Oncology, University of Torino Medical School
- Daniela De Zio
- Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- Francesco Cecconi
- Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center
- DOI
- https://doi.org/10.1038/s41467-019-12094-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity.
