The Amsterdam Ultra-high field adult lifespan database (AHEAD): A freely available multimodal 7 Tesla submillimeter magnetic resonance imaging database
Anneke Alkemade,
Martijn J Mulder,
Josephine M Groot,
Bethany R Isaacs,
Nikita van Berendonk,
Nicky Lute,
Scott JS Isherwood,
Pierre-Louis Bazin,
Birte U Forstmann
Affiliations
Anneke Alkemade
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, , Nieuwe Achtergracht 129B | Room G3.08, Postbus 15926,1001 NK Amsterdam, The Netherlands; Corresponding author.
Martijn J Mulder
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, , Nieuwe Achtergracht 129B | Room G3.08, Postbus 15926,1001 NK Amsterdam, The Netherlands; Psychology and Social Sciences, University of Utrecht, Utrecht, The Netherlands
Josephine M Groot
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, , Nieuwe Achtergracht 129B | Room G3.08, Postbus 15926,1001 NK Amsterdam, The Netherlands
Bethany R Isaacs
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, , Nieuwe Achtergracht 129B | Room G3.08, Postbus 15926,1001 NK Amsterdam, The Netherlands; Department of Experimental Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands
Nikita van Berendonk
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, , Nieuwe Achtergracht 129B | Room G3.08, Postbus 15926,1001 NK Amsterdam, The Netherlands
Nicky Lute
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, , Nieuwe Achtergracht 129B | Room G3.08, Postbus 15926,1001 NK Amsterdam, The Netherlands; Clinical Neuropsychology, Vrije University, Amsterdam, The Netherlands
Scott JS Isherwood
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, , Nieuwe Achtergracht 129B | Room G3.08, Postbus 15926,1001 NK Amsterdam, The Netherlands
Pierre-Louis Bazin
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, , Nieuwe Achtergracht 129B | Room G3.08, Postbus 15926,1001 NK Amsterdam, The Netherlands; Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, Germany
Birte U Forstmann
Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, , Nieuwe Achtergracht 129B | Room G3.08, Postbus 15926,1001 NK Amsterdam, The Netherlands
Normative databases allow testing of novel hypotheses without the costly collection of magnetic resonance imaging (MRI) data. Here we present the Amsterdam Ultra-high field adult lifespan database (AHEAD). The AHEAD consists of 105 7 Tesla (T) whole-brain structural MRI scans tailored specifically to imaging of the human subcortex, including both male and female participants and covering the entire adult life span (18–80 yrs). We used these data to create probability maps for the subthalamic nucleus, substantia nigra, internal and external segment of the globus pallidus, and the red nucleus. Data was acquired at a submillimeter resolution using a multi-echo (ME) extension of the second gradient-echo image of the MP2RAGE sequence (MP2RAGEME) sequence, resulting in complete anatomical alignment of quantitative, R1-maps, R2*-maps, T1-maps, T1-weighted images, T2*-maps, and quantitative susceptibility mapping (QSM). Quantitative MRI maps, and derived probability maps of basal ganglia structures are freely available for further analyses.
