Potential of combination therapy in patients with hypertension and dyslipidemia

Abstract

This article provides an overview of data on the role of hypertension and dyslipidemia as the leading factors determining the clinical course of athero sclerotic diseases. The need for a multifactorial approach to the treatment of patients with multiple risk factors for the progression of such diseases is noted. The article describes the results of large-scale international studies confirming the clinical benefits of combined antihypertensive and lipid-lowering therapy. From the point of view of current clinical guidelines and the available evidence base, the potential for improving adherence to treatment using a combination of anti hypertensive and lipid-lowering drugs are presented. The article discusses the prospects for optimizing the therapy of comorbid patients using a triple fixed-dose combination, including amlodipine, atorvastatin and perindopril.

Keywords

• hypertension
• coronary artery disease
• dyslipidemia
• fixed-dose combination
• compliance