Chronic Hepatitis С in Siberian Federal District: Analysis of a Case Rate and Evolution of Genotypes of the Originator

Abstract

Introduction.The chronic hepatitis C is essential for health care of the Siberian federal district in the territory of which now the incidence of the specified pathology significantly exceeds similar indicators across the Russian Federation. Materials and methods. The retrospective analysis of an epidemiological situation onе the chronic hepatitis C in the Siberian federal district for 2006–2015 included case rate assessment with use of official statistical materials. For integrated assessment of an epidemiological situation indicators of a case rate of the chronic hepatitis C and statistical criteria are used: a standard deviation and rate of a gain of a case rate and also an algorithm of calculation of an integrated indicator in the form of presentation coefficient. A genotypical variety of a virus of hepatitis C (HCV) during 2001‒2017 was studied according to the Irkutsk regional clinical consulting and diagnostic center on the basis of the analysis of 13236 PCR-positive blood samples of the sick. The chronic hepatitis C living in the territory of the Irkutsk region. Results and discussion. Assessment of the movement of a case rate of the chronic hepatitis C for the surveyed long-term period on the federal districts of Russia from the West on the East taped its body height in the designated direction. Complex assessment of indicators of a case rate in the administrative territories which are a part of the Siberian federal district in some cases significantly differs from its standard estimates and the most safe territories the Republic of Buryatia and the Omsk region. The Republic of Tyva moved from the first to the eighth rank place. Integrated approach of studying of the key epidemiological indicators allows to carry out deeper comparative assessment of the situation. In distribution of the main genotypes of HCV significant depression of the first and augmentation of the third of genotypes of the chronic hepatitis C originator is observed in recent years.Conclusions. 1 Siberian federal district is the territory of risk for chronic hepatitis C. 2 The generalized case rate indicator reflects implications of epidemic process more objectively. 3 The offered methodical approach, besides a case rate, can be used for profound assessment and other indicators. 4 Processes of globalization and social conditions promote evolution in distribution of the main genotypes of HCV.

Keywords

• chronic hepatitis c
• morbidity
• the integrated incidence rate
• the evolution of genotypes of the hepatitis c virus
• the siberian federal district