GENETIC FACTORS OF SEPSIS IN CHILDREN

Abstract

The genetic fi ngerprint holds a major relevance in the apparition, evolution and prognosis of infections. The paper focuses on polymorphisms for one nucleotide (SNPs) of the genes which encode proteins with the main role in recognizing pathogens (Toll-like receptors: TLR2, TLR4, TLR5) or in the infl ammatory response (TNFα, IL6, IL10) and which determine the severity and the type of the infection. The allelic confi guration constitutes an important risk element for corioamniotitis, prematurity, sepsis and death. It can also be a growth factor in resistance to common infections. Post-septic immunodepression infl uences late mortality of children who have suffered from infectious shock.

Keywords

• genetic polymorphism
• infections
• death risk