Vaccines (Jan 2022)
Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program
- Mamiko Onuki,
- Kasumi Yamamoto,
- Hideaki Yahata,
- Hiroyuki Kanao,
- Koji Horie,
- Katsuyuki Konnai,
- Ai Nio,
- Kazuhiro Takehara,
- Shoji Kamiura,
- Naotake Tsuda,
- Yuji Takei,
- Shogo Shigeta,
- Hidekatsu Nakai,
- Hiroyuki Yoshida,
- Takeshi Motohara,
- Tatsuya Kato,
- Keiichiro Nakamura,
- Junzo Hamanishi,
- Nobutaka Tasaka,
- Mitsuya Ishikawa,
- Nobuhiro Kado,
- Yusuke Taira,
- Mayuyo Mori,
- Takashi Iwata,
- Fumiaki Takahashi,
- Iwao Kukimoto,
- Hiroyuki Yoshikawa,
- Nobuo Yaegashi,
- Koji Matsumoto,
- for the MINT Study Group
Affiliations
- Mamiko Onuki
- Department of Obstetrics and Gynecology, School of Medicine, Showa University, Tokyo 142-8666, Japan
- Kasumi Yamamoto
- Department of Gynecologic Oncology, Hyogo Cancer Center, Akashi 673-0021, Japan
- Hideaki Yahata
- Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
- Hiroyuki Kanao
- Department of Gynecology, Cancer Institute Hospital, Tokyo 135-0063, Japan
- Koji Horie
- Department of Gynecology, Saitama Cancer Center, Saitama 362-0806, Japan
- Katsuyuki Konnai
- Department of Gynecology, Kanagawa Cancer Center, Yokohama 241-8515, Japan
- Ai Nio
- Gynecology Service, NHO Kyushu Cancer Center, Fukuoka 811-1395, Japan
- Kazuhiro Takehara
- Department of Gynecologic Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama 791-0280, Japan
- Shoji Kamiura
- Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, Japan
- Naotake Tsuda
- Department of Obstetrics and Gynecology, School of Medicine, Kurume University, Kurume 830-0011, Japan
- Yuji Takei
- Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke 329-0498, Japan
- Shogo Shigeta
- Department of Obstetrics and Gynecology, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan
- Hidekatsu Nakai
- Department of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan
- Hiroyuki Yoshida
- Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan
- Takeshi Motohara
- Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
- Tatsuya Kato
- Department of Obstetrics and Gynecology, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan
- Keiichiro Nakamura
- Department of Obstetrics and Gynecology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama 700-8558, Japan
- Junzo Hamanishi
- Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
- Nobutaka Tasaka
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
- Mitsuya Ishikawa
- Department of Gynecology, National Cancer Center Hospital, Tokyo 104-0045, Japan
- Nobuhiro Kado
- Division of Gynecology, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan
- Yusuke Taira
- Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, Japan
- Mayuyo Mori
- Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
- Takashi Iwata
- Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan
- Fumiaki Takahashi
- Division of Medical Engineering, Department of Information Science, Iwate Medical University, Yahaba 028-3694, Japan
- Iwao Kukimoto
- Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo 208-0011, Japan
- Hiroyuki Yoshikawa
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
- Nobuo Yaegashi
- Department of Obstetrics and Gynecology, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan
- Koji Matsumoto
- Department of Obstetrics and Gynecology, School of Medicine, Showa University, Tokyo 142-8666, Japan
- for the MINT Study Group
- DOI
- https://doi.org/10.3390/vaccines10020188
- Journal volume & issue
-
Vol. 10,
no. 2
p. 188
Abstract
Since the human papillomavirus (HPV) vaccination program for Japanese girls aged 12–16 years began in 2010, vaccination uptake has been low in women born before 1993 but high (approximately 70%) in those born during 1994–1999. We previously compared the prevalence of vaccine types HPV16 and HPV18 in cervical intraepithelial neoplasia grade 1–3 (CIN1–3) or adenocarcinoma in situ (AIS) between vaccinated and unvaccinated cohorts and found direct protection effects among vaccinated women in Japan. In this study, we focused on changes in HPV16/18 prevalence among “unvaccinated” cohorts with CIN/AIS. We analyzed HPV16/18 prevalence among 5051 unvaccinated women aged trend = 0.03) and CIN2–3/AIS (62.5–36.4%, Ptrend = 0.07) among women aged p = 0.04). Significant reduction in HPV16/18 prevalence among young unvaccinated women with CIN1 and CIN2–3/AIS suggests herd effects of HPV vaccination in Japan.
Keywords
- adenocarcinoma in situ
- cervical cancer
- cervical intraepithelial neoplasia
- human papillomavirus
- vaccination
