Nature Communications (Oct 2021)
Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma
- Weilin Pu,
- Xiao Shi,
- Pengcheng Yu,
- Meiying Zhang,
- Zhiyan Liu,
- Licheng Tan,
- Peizhen Han,
- Yu Wang,
- Dongmei Ji,
- Hualei Gan,
- Wenjun Wei,
- Zhongwu Lu,
- Ning Qu,
- Jiaqian Hu,
- Xiaohua Hu,
- Zaili Luo,
- Huajun Li,
- Qinghai Ji,
- Jiucun Wang,
- Xiaoming Zhang,
- Yu-Long Wang
Affiliations
- Weilin Pu
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Xiao Shi
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Pengcheng Yu
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Meiying Zhang
- The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Zhiyan Liu
- Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Licheng Tan
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Peizhen Han
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Yu Wang
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Dongmei Ji
- Department of Oncology, Shanghai Medical College, Fudan University
- Hualei Gan
- Department of Oncology, Shanghai Medical College, Fudan University
- Wenjun Wei
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Zhongwu Lu
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Ning Qu
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Jiaqian Hu
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Xiaohua Hu
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
- Zaili Luo
- Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center
- Huajun Li
- Department of Clinical Research & Development, Jiangsu Hengrui Pharmaceuticals Co., Ltd.
- Qinghai Ji
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- Jiucun Wang
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
- Xiaoming Zhang
- The Center for Microbes, Development and Health, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences
- Yu-Long Wang
- Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-26343-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
The characterisation of the papillary thyroid carcinoma (PTC) tumour microenvironment remains crucial. Here, the authors perform single-cell RNA sequencing in 11 patients and identify potential opportunities for the use of immunotherapy and its combination with anti-angiogenic therapy in PTC.
