Zhongguo quanke yixue (Jul 2023)
Executive Function of GO/NOGO Paradigm Experiment in Children with Bronchial Asthma and Its Relationship with Pulmonary Function
Abstract
Background Children with asthma may have deficits in executive functioning, affecting the quality of life and mental health of children. However, there are few studies on the relationship between executive function and pulmonary function. Objective To investigate whether executive dysfunction is comorbid and its specific manifestations and analyze the relationship between executive function and pulmonary function in children with bronchial asthma. Methods A total of 35 children diagnosed with bronchial asthma in the pediatric outpatient of the Third Affiliated Hospital of Soochow University (the First People's Hospital of Changzhou) from June 2020 to April 2022 were selected as the children with asthma group, and 35 healthy children were included in the pediatric outpatient of the Third Affiliated Hospital of Soochow University (the First People's Hospital of Changzhou) as the healthy control group. The GO/NOGO experiment was used to collect the executive function indexes and detect the pulmonary function. Pearson correlation analysis and Spearman rank correlation analysis were used to explore the relationship between executive function indexes and pulmonary function test indices. Results The number of hits in the children with asthma group was lower than that in the healthy control group, and the response time, response time variability and missed reporting errors were higher than those in healthy control group (P<0.05). The results of Pearson correlation analysis /Spearman rank correlation analysis showed that response time was negatively correlated with maximum vital capacity (VCmax) and forced vital capacity (FVC) in children with asthma, and response time variability was negatively correlated with VCmax, FVC and forced expiratory volume in one second (P<0.05). The number of missed reports was positively correlated with percent predicted forced vital capacity (P<0.05) . Conclusion Compared with healthy children, children with asthma perform sustained attentional deficits and reaction rate deficits, and the executive function indexes of children with asthma is correlated with pulmonary function test indices, mainly manifested in sustained attention, reaction speed decreased.
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