Scientific Reports (Apr 2025)
Lymphocyte to monocyte ratio and lymphocyte to neutrophil ratio in neurosyphilis may affect the response to therapy and diagnostic efficacy
Abstract
Abstract To investigate the effects of lymphocyte to monocyte ratio (LMR), lymphocyte to neutrophil ratio (LNR), and serum toluidine red unheated serum test (sero-TRUST) titers on the therapy response of HIV negative neurosyphilis (NS) patients after initial therapy. HIV negative NS patients who received initial therapy at the Second Hospital of Nanjing were selected as the research participants, and demographic data, as well as clinical and laboratory data, were collected through follow-up.Group the study population based on response to therapy status, with complete response to therapy as the endpoint of the study. Cox regression analysis of factors influencing response to therapy after initial therapy. Time-dependent ROC curve evaluation of LMR and LNR prediction ability. Among the 249 patients included in this study, 200 were in the response to therapy group and 49 were in the therapy non-response to therapy group. Cox regression analysis found that baseline blood LMR > 1.93, LNR > 0.3, and sero-TRUST titer > 1:16 can affect the response to therapy outcomes. However, there was no statistically significant difference between LMR and LNR with and without response in the therapy group. The time-dependent ROC curve shows that the AUC for evaluating response to therapy is moderately sensitive based on baseline sero-TRUST titers, or LNR after 3 months of therapy, sero-TRUST difference from baseline. Baseline blood LMR > 1.93 and sero-TRUST titers ≥ 1:16 may be important prognostic factors affecting response to therapy in HIV negative NS patients. Baseline sero-TRUST titer > 1:16, LNR increase > 0.12 or sero-TRUST titer decrease > 2-fold after 3 months of therapy can be used as auxiliary indicators to evaluate the occurrence of therapy response in patients.
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