BMJ Open (Dec 2020)
Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia
- David Brown,
- Annelies Wilder-Smith,
- Marília Dalva Turchi,
- Adriana Tami,
- Antoni Soriano-Arandes,
- Maria Elisabeth Moreira,
- Demócrito de Barros Miranda-Filho,
- Marion Koopmans,
- Thomas Jaenisch,
- Patrícia Brasil,
- Ricardo Arraes de Alencar Ximenes,
- Luana Damasceno,
- Barry Rockx,
- Wayner Vieira De souza,
- Philippe Mayaud,
- Elizabeth B Brickley,
- Carlo Giaquinto,
- Bruno Hoen,
- Daniel Lang,
- Neal Alexander,
- A E Ades,
- Xavier de Lamballerie,
- Ulisses Ramos Montarroyos,
- Celina Maria Turchi Martelli,
- Thalia Velho Barreto de Araújo,
- Claire Thorne,
- Fabiana Gordon,
- Ernesto T A Marques,
- Adriana Gomez,
- Vivian I Avelino-Silva,
- Moritz Pohl,
- Kerstin D Rosenberger,
- Sarah Esperanza Bethencourt Castillo,
- Victor Hugo Borja Aburto,
- Celia D C Christie,
- Jose Eduardo Gotuzzo H,
- Mauro Martins Teixeira,
- Maria Consuelo Miranda,
- J Glenn Morris,
- Paola Mariela Saba Villarroel,
- Carmen Soria Segarra,
- Joshua Anzinger,
- Valery Beau De Rochars,
- Maria de Fatima Albuquerque,
- Rafael F O França,
- Hugo Lopez-Gatell Ramirez,
- Maria G Guzman,
- Rigan Louis,
- Anyela Lozano,
- Eric Martinez,
- Ricard Ortiz Serrano,
- Silvia P Salgado,
- Aluizio Augusto Segurado,
- Zilton F M Vasconcelos,
- Isabelle Freire Tabosa,
- Luis Angel Villar
Affiliations
- David Brown
- 2Department of Immunology, Westmead Hospital, Sydney, NSW, Australia
- Annelies Wilder-Smith
- London School of Hygiene & Tropical Medicine, London, London, UK
- Marília Dalva Turchi
- Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia, Brazil
- Adriana Tami
- Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, The Netherlands
- Antoni Soriano-Arandes
- Paediatric Infectious Diseases and Immunodeficiencies Unit, Children’s Hospital, Hospital Vall d`Hebron, Barcelona, Spain
- Maria Elisabeth Moreira
- Department of Neonatology, Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil
- Demócrito de Barros Miranda-Filho
- Departamento de Medicina Interna, Universidade de Pernambuco, Recife, PE, Brasil
- Marion Koopmans
- Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
- Thomas Jaenisch
- Department of Infectious Diseases, Section Clinical Tropical Medicine, UniversitatsKlinikum Heidelberg, Heidelberg, Germany
- Patrícia Brasil
- Instituto de pesquisa Clínica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
- Ricardo Arraes de Alencar Ximenes
- Departamento de Medicina Interna, Universidade de Pernambuco, Recife, PE, Brasil
- Luana Damasceno
- Barry Rockx
- Department of Viroscience, Erasmus Universiteit Rotterdam, Rotterdam, Zuid-Holland, The Netherlands
- Wayner Vieira De souza
- Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil
- Philippe Mayaud
- 2 Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK
- Elizabeth B Brickley
- Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK
- Carlo Giaquinto
- 10 Department of Woman’s and Child’s Health, University of Padova, Padua, Italy
- Bruno Hoen
- Service de Maladies Infectieuses et Tropicales, CHRU de Nancy, Vandoeuvre-les-Nancy, France
- Daniel Lang
- University of Toronto Ontario Institute for Studies in Education, Toronto, Ontario, Canada
- Neal Alexander
- Faculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
- A E Ades
- 1University of Bristol, Bristol, UK
- Xavier de Lamballerie
- Unité des Virus Émergents, IRD 190-Inserm 1207, Aix-Marseille University, Marseille, France
- Ulisses Ramos Montarroyos
- Instituto de Ciências Biológicas, Universidade de Pernambuco, Recife, PE, Brasil
- Celina Maria Turchi Martelli
- Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil
- Thalia Velho Barreto de Araújo
- Postgraduate Programme in Public Health, Federal University of Pernambuco, Recife, Brazil, Recife, Brazil
- Claire Thorne
- Integrated Screening Outcomes Surveillance Service, part of the NHS Infectious Diseases in Pregnancy Screening programme, based at UCL Great Ormond Street Institute of Child Health, London, UK
- Fabiana Gordon
- Population Health Sciences, University of Bristol, Bristol, UK
- Ernesto T A Marques
- Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil
- Adriana Gomez
- 6UMIT- Clínica Tolima- Universidad del Tolima, Ibagué, Colombia
- Vivian I Avelino-Silva
- AIDS Healthcare Foundation Global Program, Los Angeles, California, USA
- Moritz Pohl
- biostatistician
- Kerstin D Rosenberger
- Department of Infectious Diseases, Section Clinical Tropical Medicine, UniversitatsKlinikum Heidelberg, Heidelberg, Germany
- Sarah Esperanza Bethencourt Castillo
- Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela
- Victor Hugo Borja Aburto
- Mexican Institute of Social Security, Mexico City, Mexico
- Celia D C Christie
- Department of Child and Adolescent Health, University of the West Indies at Mona, Kingston, Jamaica
- Jose Eduardo Gotuzzo H
- Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
- Mauro Martins Teixeira
- Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
- Maria Consuelo Miranda
- Universidad Industrial de Santander, Bucaramanga, Colombia
- J Glenn Morris
- Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA
- Paola Mariela Saba Villarroel
- Centro Nacional de Enfermedades Tropicales, Santa Cruz de la Sierra, Santa Cruz de la Sierra, Bolivia
- Carmen Soria Segarra
- Universidad Católica de Santiago de Guayaquil, Guayaquil, Guayas, Ecuador
- Joshua Anzinger
- Valery Beau De Rochars
- Maria de Fatima Albuquerque
- Rafael F O França
- Hugo Lopez-Gatell Ramirez
- Maria G Guzman
- Rigan Louis
- Anyela Lozano
- Eric Martinez
- Ricard Ortiz Serrano
- Silvia P Salgado
- Aluizio Augusto Segurado
- Zilton F M Vasconcelos
- Isabelle Freire Tabosa
- Luis Angel Villar
- DOI
- https://doi.org/10.1136/bmjopen-2019-035307
- Journal volume & issue
-
Vol. 10,
no. 12
Abstract
Introduction Zika virus (ZIKV) infection in pregnancy has been associated with microcephaly and severe neurological damage to the fetus. Our aim is to document the risks of adverse pregnancy and birth outcomes and the prevalence of laboratory markers of congenital infection in deliveries to women experiencing ZIKV infection during pregnancy, using data from European Commission-funded prospective cohort studies in 20 centres in 11 countries across Latin America and the Caribbean.Methods and analysis We will carry out a centre-by-centre analysis of the risks of adverse pregnancy and birth outcomes, comparing women with confirmed and suspected ZIKV infection in pregnancy to those with no evidence of infection in pregnancy. We will document the proportion of deliveries in which laboratory markers of congenital infection were present. Finally, we will investigate the associations of trimester of maternal infection in pregnancy, presence or absence of maternal symptoms of acute ZIKV infection and previous flavivirus infections with adverse outcomes and with markers of congenital infection. Centre-specific estimates will be pooled using a two-stage approach.Ethics and dissemination Ethical approval was obtained at each centre. Findings will be presented at international conferences and published in peer-reviewed open access journals and discussed with local public health officials and representatives of the national Ministries of Health, Pan American Health Organization and WHO involved with ZIKV prevention and control activities.
