Nature Communications (Aug 2017)

Matrix degradability controls multicellularity of 3D cell migration

  • Britta Trappmann,
  • Brendon M. Baker,
  • William J. Polacheck,
  • Colin K. Choi,
  • Jason A. Burdick,
  • Christopher S. Chen

DOI
https://doi.org/10.1038/s41467-017-00418-6
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 8

Abstract

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The fabrication of vascularized 3D tissues requires an understanding of how material properties govern endothelial cell invasion into the surrounding matrix. Here the authors integrate a non-swelling synthetic hydrogel with a microfluidic device to study chemokine gradient-driven angiogenic sprouting and find that matrix degradability modulates the collectivity of cell migration.