Communications Biology (Mar 2021)

T cells in the brain may contribute to attenuation of sepsis-associated depression

  • Karli Montague-Cardoso

DOI
https://doi.org/10.1038/s42003-021-01923-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 2

Abstract

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Sepsis-associated encephalopathy, as well as increasing mortality, has been associated with long-lasting depressive behaviour, which is thought to be caused by infection-induced neuroinflammation in the brain. Saito et al. have recently demonstrated in a mouse model of sepsis that infiltrated regulatory T cells in the cerebral cortex mediate the resolution of neuroinflammation and alleviate anxious/depressive behaviour. Their study paves the way for further research that investigates the role of T cells in the underlying mechanisms mediating recovery of sepsis-associated depression.