Nature Communications (Jul 2021)
SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts
- Jun Sun,
- Dong Yeon Shin,
- Mark Eiseman,
- Alisha R. Yallowitz,
- Na Li,
- Sarfaraz Lalani,
- Zan Li,
- Michelle Cung,
- Seoyeon Bok,
- Shawon Debnath,
- Sofia Jenia Marquez,
- Tommy E. White,
- Abdul G. Khan,
- Ivo C. Lorenz,
- Jae-Hyuck Shim,
- Francis S. Lee,
- Ren Xu,
- Matthew B. Greenblatt
Affiliations
- Jun Sun
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Dong Yeon Shin
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Mark Eiseman
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Alisha R. Yallowitz
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Na Li
- State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- Sarfaraz Lalani
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Zan Li
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Michelle Cung
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Seoyeon Bok
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Shawon Debnath
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Sofia Jenia Marquez
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Tommy E. White
- Tri-Institutional Therapeutics Discovery Institute
- Abdul G. Khan
- Tri-Institutional Therapeutics Discovery Institute
- Ivo C. Lorenz
- Tri-Institutional Therapeutics Discovery Institute
- Jae-Hyuck Shim
- Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School
- Francis S. Lee
- Department of Psychiatry, Weill Cornell Medical College
- Ren Xu
- State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- Matthew B. Greenblatt
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41467-021-24819-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Hedgehog signaling is essential for bone formation. Here, the authors show that the transmembrane protein SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, suggesting it may be a potential therapeutic target to enhance bone formation.
