Two Dibenzylbutyrolactol Derivatives and Other Chemical Constituents from Aristolochia peltato-deltoidea

Abstract

The hexane extract from the aerial parts of Aristolochia peltato-deltoidea Hoehne (Aristolochiaceae) afforded two new epimeric lignans of the type dibenzylbutyrolactol, rel-(8R, 8?S, 9S)-3,4-dimethoxy-3?,4?-methylenedioxy-9beta-ethoxy- and rel-(8R, 8?S, 9R)-3,4-dimethoxy-3?,4?-methylenedioxy-9alpha-ethoxy-lignans-8.8?,9.O.9?, besides a benzofuran neolignan, known as eupomatenoid-7, alpha-tocopherylquinone, beta-sitosterol and stigmasterol. From the chloroform extract were isolated two diastereomeric dibenzylbutyrolactone lignans: rel-(8R, 8?R)- and rel-(8R, 8?S)-3,4-dimethoxy-3?,4?-methylenedioxy-9-oxo-lignans-8.8?,9.O.9?. Chemical composition analysis by GC/MS of the non polar fractions from the hexane extract was also carried out and ten components were identified. The structures of the isolated compounds were elucidated utilizing spectrometric methods.

Keywords

• Aristolochia peltato-deltoidea
• Aristolochiaceae
• benzofuran neolignan
• dibenzylbutyrolactol lignans
• alpha-tocopherylquinone