ATase inhibition rescues age-associated proteotoxicity of the secretory pathway

Abstract

Murie et al use in silico docking and affinity binding to identify ATase1 and ATase2 specific inhibitors, and AT1 sTg and APP/PS1 mice to test their translational potential. Their study suggests that ATase-targeting approaches might offer a translational pathway for many ageassociated proteopathies affecting the ER/secretory pathway